Digital Transformation is shaping the new industrial landscape. A new wave of Industry 4.0 possibilities and solutions has risen. Cloud solutions, Mobility, Digital Twinning, Augmented Reality, Data Analytics, etc. Both Connectivity Technologies and Advanced Manufacturing Technologies are forging a new path for manufacturers to embrace new models and revenue streams tapping new business sectors, to predict malfunctions, to manage efficiently the product life cycle, to right answer the demand and to be competitive in the speed to market. In this panel we will discuss these greatest challenges of transitioning to these new technologies as well as those ones related to modernizing the legacy systems, which seems to be at the heart for achieving the full benefit of digitization and enter into the next level of production competitiveness.